These factors include i) milling time-related parameters (pause time, number of milling cycles and time of each cycle), ii) speed, iii) milling ball size, and iv) solid to solvent ratio. Nanosization by planetary ball mill significantly resulted in enhancing the dissolution rate and bioavailability of different drugs, like clarithromycin 5 and
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The mixtures were milled in a high energy ball mill (pulverisette 4 Vario-Plantary Mill, Fritsch) with a ball to powder weight ratio of 10:1 and ethanol as process control agent. The steel vial of the ball mill had 250 ml capacity. 21.858 g of powders were put into the container and equal number of steel balls of 1 and 2 cm in diameters were added.
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In the first-part, two excipients (HPMC and soluplus) were selected from seven, and the optimal ball-milling parameters of speed and time (18 Hz, 15 min) were determined based on solubility-enhancement and flow-ability criteria.
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These factors include i) milling time-related parameters (pause time, number of milling cycles and time of each cycle), ii) speed, iii) milling ball size, and iv) solid to solvent ratio. Nanosization by planetary ball mill significantly resulted in enhancing the dissolution rate and bioavailability of different drugs, like clarithromycin 5 and
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The effect of time and frequency of the ball milling process on the extrudates were determined. The ball milling frequency was set 20, 30, or 40 Hz and the milling time to 30 min. Then, the milling time was set to 30, 40, and 50 min at milling frequency of 30 Hz. The samples were fed into the extrusion system.
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In the first-part, two excipients (HPMC and soluplus) were selected from seven, and the optimal ball-milling parameters of speed and time (18 Hz, 15 min) were determined based on solubility-enhancement and flow-ability criteria.
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In the present work, a set of Cu-based powder mixtures containing up to 6 wt% Cr has been processed through mechanical alloying for a range of milling times up to 96 h. The mixtures were processed in a ball mill with ball to powder ratio of 10:1 and the equal numbers of 1 and 2 cm balls. The processed powder mixtures were investigated by scanning electron microscope, optical microscopic
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The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ball-milling time was varied from 10 to 100 hours. The ball-milled alloys were consolidated under uniaxial pressure of 3GPa at room temperature. The solid solubility of V
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solubility of the pure drug and its physical dispersions. Using ball milling technique the physical dispersions of Nimesulide with the polymers, prepared in the ratios of 1:1, 1:3, 1:5 were subjected to size reduction for two different time intervals of 30 min and 90 min,
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Electrochemical kinetic parameters for carbon steel powders produced by high-energy ball milling for 2, 3, and 5 h and immersed in NaOH and NaCl solutions are tabulated in Table 2. The results were obtained from the deconstruction of polarization curves in terms of the superposition model and the mixed-potential theory [ 44 , 45 ].
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The mixtures were milled in a high energy ball mill (pulverisette 4 Vario-Plantary Mill, Fritsch) with a ball to powder weight ratio of 10:1 and ethanol as process control agent. The steel vial of the ball mill had 250 ml capacity. 21.858 g of powders were put into the container and equal number of steel balls of 1 and 2 cm in diameters were added.
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The study was a pioneering attempt to assess the influence of the structural polymorphism (forms I, II, III) of benzocaine on its solubility, apparent solubility, and chemical stability, which are vital parameters for preformulation and formulation work.
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In this study, chitosan flake was micronized in a ball mill to make fine powder. The effects of the milling on properties of chitosan, such as particle size, molecular parameters, bulk density, crystalline structure, color, chemical structure, and solubility, were investigated.
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Ball mill based on co-milling, a promising way to enhance solubility of poorly soluble drugs employing norfloxacin as model drug January 2018 Acta Poloniae Pharmaceutica 75(1):155-165
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Exfoliation rates in planetary ball mills can be improved when combining the milling with sonication [57] or when designed molecules are added, for example, 1-pyrene carboxylic acid [96] or
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Subsequently, appropriate amounts of n-Hexane (AR, CAS:110–54–3) were added and the ball milling process was conducted for 5 h at the rotational speed of 300 rpm using a high energy planetary ball mill (MITR QM-QX-2L). n-Hexane was used to avoid the agglomeration of particles during the milling. 32 After the termination of ball milling, the
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By 10 h of ball milling with the optimized milling parameters, D50 and WC grain size of the ball milled WC–Co powder were about 400 nm and 10 nm, respectively. Main effects on WC grain size (a
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Exfoliation rates in planetary ball mills can be improved when combining the milling with sonication [57] or when designed molecules are added, for example, 1-pyrene carboxylic acid [96] or
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The effects of milling parameters such as balls diameters and ball milling speed defined by the number of balls from vials is an important parameter a milling process. extended solubility
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In the present work, a set of Cu-based powder mixtures containing up to 6 wt% Cr has been processed through mechanical alloying for a range of milling times up to 96 h. The mixtures were processed in a ball mill with ball to powder ratio of 10:1 and the equal numbers of 1 and 2 cm balls. The processed powder mixtures were investigated by scanning electron microscope, optical microscopic
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The end mill speed is calculated with the following formula: n [rpm] = (vc [m/min] *1000) / 3.14 * ø d1 [mm]) Example calculation: vc = 500 m/min (selected from chart) d = ø 8 mm. 19904 rpm = ( 500 *1000) / (3.14 * 8) If the maximum speed of the milling motor is lower than the calculated value, the maximum speed of the milling motor needs to
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-Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic technique were carried out at
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A simple ball milling route to the tetrayanoborate anion is presented: The K[B(CN)4] synthesis is one fine example, how a synthesis problem based on solubility may be solved by a ball milling
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The damaged starch content and solubility of wheat starch (A), A-type (B) and B-type (C) starch granules after ball milling treatment for different time. 10 min, 20 min, 30 min, 40 min and 60 min refer to ball milling time.
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Ball milling is used in the pharmaceutical industry to reduce the size of particulate material such as pharmaceutical granules. Dr Alexander Krok and Dr Sandra Lenihan from Munster Technological University, Ireland, have developed a computational approach to achieve optimal, energy-efficient size reduction in ball milling resulting in the production of high-quality particulate material (i.e
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Major parameters for ball milling Temperature Ball milling should be considered as a potentially attractive solution for solvent-free synthesis. 21
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By 10 h of ball milling with the optimized milling parameters, D50 and WC grain size of the ball milled WC–Co powder were about 400 nm and 10 nm, respectively. Main effects on WC grain size (a
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However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of unstable amorphous parts.
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The effects of milling parameters such as balls diameters and ball milling speed defined by the number of balls from vials is an important parameter a milling process. extended solubility
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The effect of time and frequency of the ball milling process on the extrudates were determined. The ball milling frequency was set 20, 30, or 40 Hz and the milling time to 30 min. Then, the milling time was set to 30, 40, and 50 min at milling frequency of 30 Hz. The samples were fed into the extrusion system.
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